http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107129501-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-18 |
| filingDate | 2017-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107129501-B |
| titleOfInvention | Diabetes B drug sitagliptin novel preparation method |
| abstract | The invention discloses a kind of diabetes B drug sitagliptin novel preparation methods.Invention does fluoro reagent starting material using the trifluoro-benzene of cheaper, pass through effective acylation with L-Aspartic acid, success synthesizes the basic framework of sitagliptin, from initial raw material to final product, synthetic route is all totally different from scheme disclosed in the prior art, and optimize route, chiral source is done using the natural L-Aspartic acid that raw material is easy to get, successfully synthesize optically pure sitagliptin product, avoid the complexity of asymmetry catalysis and fractionation in prior art use, also effectively solve the problems, such as wherein trifluoro-benzene friedel-crafts acylation synthesis sitagliptin basic framework low yield, improve yield, and cost is lower, more convenient operation, it is more suitable for industrialized production, it is simpler than prior art synthetic route, operability is stronger. |
| priorityDate | 2017-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.