http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107118207-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-635 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-42 |
| filingDate | 2017-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107118207-B |
| titleOfInvention | Preparation method of CDK inhibitor |
| abstract | The invention discloses a preparation method of a CDK inhibitor, which comprises the steps of reacting monomethyl thiourea with 1-chloropropone to obtain N, 4-dimethylthiazole-2-amine, carrying out bromination reaction to obtain 5-bromo-N, 4-dimethylthiazole-2-amine, and then reacting with boric acid ester under the action of a catalyst to obtain an aromatic boric acid ester intermediate; carrying out suzuki coupling reaction on the aromatic borate intermediate and 2, 4-dichloro-5 fluorouracil under the catalysis of a palladium catalyst to obtain a coupling product, and then continuing carrying out Buchwald-Hartwig reaction on the coupling product and aromatic amine to finally obtain a target product. |
| priorityDate | 2017-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 175.