| abstract |
The invention discloses a preparation method of a CDK inhibitor. Monomethylthiourea is reacted with 1-chloroacetone to obtain N,4-dimethylthiazol-2-amine, and 5-bromo-N is obtained through bromination reaction. 4-dimethylthiazole-2-amine, and then obtain an aromatic borate intermediate with a borate under the action of a catalyst; the aromatic borate intermediate and 2,4-dichloro-5 fluorouracil are catalyzed by a palladium catalyst The Suzuki coupling reaction occurs below to obtain the coupled product, and then continues to undergo Buchwald-Hartwig reaction with aromatic amines to finally obtain the target product. |