http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107118144-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-08 |
| filingDate | 2016-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107118144-B |
| titleOfInvention | Reductive preparation process of etimibe and its intermediates |
| abstract | The invention provides a method for preparing etimibe as shown in formula II and an intermediate thereof, which comprises the following steps: in an organic solvent, under the catalysis of (R)-Me-CBS, compound I is prepared in NaBH 4 - The asymmetric reduction reaction shown below is carried out in the I 2 reduction system to obtain II; wherein R is a hydrogen atom, benzyl, tert-butyldimethylsilyl or trimethylsilyl. Compared with borane dimethyl sulfide, the NaBH 4 -I 2 reduction system used in the preparation method is more environmentally friendly, the operation is more convenient and safe, and the production cost can be reduced. The synthesis of tilimibe is more suitable for industrial production. |
| priorityDate | 2016-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.