| abstract |
The invention discloses the preparation methods of the trifluoromethyl diaryliodonium of nickel catalysis.The following steps are included: halogenated aryl hydrocarbon, fluoroform seleno tetramethyl-ammonium, Raney nickel are mixed with organophosphorus ligand or bipyridyliums compound, is reacted 5 minutes to 48 hours at subzero 80 to 100 DEG C, isolate and purify, obtain trifluoromethyl diaryliodonium.The halogenated aryl hydrocarbon includes antidepressant moclobemide or the fenofibrate for treating adult hyperlipidemia.Not only raw material is easy to get the present invention, mild condition, good reaction selectivity, yield are high, functional group compatibility is good, wide application range of substrates (being suitable for chlorinated aromatic hydrocarbons), but also requires instrument and equipment that low, technological operation is simple. |