http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107118141-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-0263 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-822 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C327-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-2409 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C327-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C327-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C327-24 |
| filingDate | 2017-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107118141-B |
| titleOfInvention | A kind of synthetic method and its intermediate of ticagrelor intermediate |
| abstract | The invention discloses a kind of synthetic methods of ticagrelor intermediate, and compound (4) first are made through coupling reaction in compound (2) and compound (3)；Ticagrelor midbody compound (1) is made through rhodium catalysis asymmetry ternary cyclization in the compound (4), and reaction equation is as follows： Synthetic method technology path of the invention is novel, easy to operate, the advantages that synthetic yield is high, good product purity, raw material are cheap and easy to get and is suitable for industrialized production, use rhodium catalysis asymmetry ternary cyclization that compound (1) is made as new catalyst system in the present invention, new system has reaction condition mild, post-processing is simple, overall cost is lower, reaction is easier to the features such as amplification, synthesized ticagrelor intermediate provides intermediate feed for ticagrelor preparation simultaneously, the important intermediate as synthesis ticagrelor. |
| priorityDate | 2017-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.