| abstract |
The present invention relates to the derivation of FGF21 proteins having cysteine residues at positions corresponding to positions 167, 169, 170, 171, 172, 173, 174, 175, especially position 180 or position 181 of mature human FGF21 substances, and derivatives thereof having a side chain attached to the cysteine. The FGF21 derivatives of the present invention exhibit high potency at the FGF receptor. The present invention also relates to pharmaceutical compositions comprising such FGF21 derivatives and pharmaceutically acceptable excipients, and the medical use of the FGF21 derivatives. |