| abstract |
Provided are tryptophan-2,3-dioxygenase (TDO) and/or indoleamine-2,3-dioxygenase (IDO) inhibitor compounds for use in medicaments, said compounds having the formula: Wherein X 1 and X 2 can be the same or different and each independently selected from C, N, O and S; X 3 , X 4 , X 5 and X 6 can be the same or different and each independently selected from C and N ; each bond indicated by the dotted line may be present or absent, provided that there is at least one such bond; R 1 , R 2 , R 3 , R 4 , R 5 and R 6 may be present or absent, and may be the same or different, and each independently selected from H and substituted or unsubstituted organic groups, provided that the number of R 1 , R 2 , R 3 , R 4 , R 5 and R 6 groups present is such that X 1 , The respective valences of X 2 , X 3 , X 4 , X 5 and X 6 ; and wherein at least one of R 5 and R 6 comprises a group Y, wherein Y is a group selected from (II), (III), ( Groups of the formulas of IV), (V), (VI), (VII): Wherein L may or may not exist, and may be a substituted or unsubstituted organic linking group; R and R may be the same or different and selected from H and a substituted or unsubstituted organic group; each R 34 may be the same or different and selected from H and substituted or unsubstituted organic groups; R 35 is selected from substituted or unsubstituted alcohol or ether groups; each R 36 may be the same or different and selected from H and Substituted or unsubstituted organic groups; X 7 can be selected from C and N; X 8 , X 9 , X 10 , X 11 , X 12 , X 13 , X 14 , X 15 and X 16 can be the same or different and each independently selected from C, N, O, and S; each bond represented by a dotted line may or may not be present; and each R may be the same or different and is selected from H and substituted or unsubstituted organic groups . |