| abstract |
The invention mainly provides a derivative of FK409 NO-donor type statin blood lipid-lowering drug and a preparation method thereof. Through in vitro activity measurement, it is found that the derivative obtained in the present invention has good NO releasing activity, and the NO released through the donor part can increase the half-life of the target compound in vivo and in vitro, thereby prolonging the action time. On the basis of the pharmacological effects of statins in lowering blood lipids, the non-lipid-lowering activities of these drugs, such as vasodilation and anti-platelet aggregation, are enhanced, and the adverse reactions caused by them are improved. The general formula of the derivative of the present invention is shown in formula <I>, |