abstract |
The present invention provides one kind and ubenimex intermediate (2S is prepared as resolution reagent using organic base, 3R) the method for the phenylbutyric acid of 3 acetylamino, 2 hydroxyl 4, wherein organic base are selected from the naphthalene ethylamines of S 1, (S) 1 (2 naphthyl) ethamine, L benzene glycinol, L phenylalaninols.Ubenimex intermediate purity prepared by the present invention is good, high income, simple to operate, favorable reproducibility, is suitable for industrialized production. |