http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107096038-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-537 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-537 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-61 |
| filingDate | 2017-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107096038-B |
| titleOfInvention | Preparation method of cross-linked nano-drug based on active reaction type one-step method |
| abstract | The invention discloses a preparation method of a cross-linked nano-drug based on an active reaction type one-step method, which comprises the following steps of adding a polymer and a drug with sulfydryl into a solution, mixing, and dialyzing to obtain the cross-linked nano-drug; the polymer side chains contain a dithiolane structure. The invention can obtain the nanometer medicine with stable circulation through simple preparation, and overcomes the defects of complex preparation, catalyst requirement and the like of the chemical bonding nanometer medicine in the prior art; the product prepared by the invention has a stable cross-linking structure, and the problem that the existing chemical bonding nano-drug is not cross-linked is avoided; on a model of B16F 10-loaded melanoma, the drug shows good treatment effect, and the tumor inhibition rate is over 90 percent, which indicates that the active targeting cross-linking nano-drug has great potential application in cancer chemotherapy. |
| priorityDate | 2017-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.