| abstract |
The invention discloses a 4,5-disubstituted-1-hydrogen-pyrrole (2,3-f) quinoline-2,7,9-tricarboxylate compound, its analogue or its derivative, its structure is as follows Shown in formula I: Wherein, R 1 and R 4 are independently selected from the following atoms or groups: hydrogen, straight chain or branched C1-8 alkyl, deuterated straight chain or branched C1-8 alkyl, aralkyl or substituted Aryl hydrocarbon group; R 2 is independently selected from the following atoms or groups: halogen, linear or branched C1-8 alkoxy, deuterated linear or branched C1-8 alkoxy; R 3 is independently selected from Atoms or groups from the following: straight-chain or branched C1-8 alkoxy, deuterated straight-chain or branched C1-8 alkoxy. The compound can be used as a reaction intermediate for the synthesis of PQQ, replacing the oxidant process of CAN used in the synthesis of PQQ in existing patents and literatures. Making the whole process cheaper and more efficient. |