http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107082743-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C319-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C315-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-755 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-755 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 |
| filingDate | 2016-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107082743-B |
| titleOfInvention | 3-substituted-1-indanone derivative compound and preparation method and pharmaceutical application thereof |
| abstract | The invention belongs to the technical field of pharmaceutical chemistry and medicine, relates to a novel tumor necrosis factor (TNF-alpha) inhibitor, and particularly relates to a micromolecule 3-aryl-1-indanone derivative TNF-alpha inhibitor and medicinal application thereof. The present invention provides a 3-substituted-1-indanone derivative compound represented by the following formula (1): the prepared derivative compound is proved to have specific inhibition effect on tumor necrosis factor (TNF-alpha) generated by macrophage RAW264.7 stimulated by LPS through in vitro experiments; the derivative can be used for preparing small molecule medicines for treating ulcerative colitis, and can be used as a TNF-alpha inhibitor of small molecules for treating immunoinflammatory diseases mediated by TNF-alpha increase in human bodies, and comprises the following components: ulcerative colitis, Crohn's disease, rheumatoid arthritis, osteoarthritis, psoriasis, and the like. |
| priorityDate | 2016-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.