| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ad21f05a44ab71bf5958d2bf1bf4cb40 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2720-12334
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55516
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-245
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-107 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-295
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate |
2017-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb2be03ec92a9adc689126e69ff10f7a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5c1c6aab78ee8bcdccccbbfb5e302aa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7842e5e452cc878d7539652daf25933c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d29fc636edc0204c8feb6e7eefcdf8f1 |
| publicationDate |
2017-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-107080840-A |
| titleOfInvention |
Rotavirus-cholera combined vaccine and preparation method thereof |
| abstract |
The invention discloses a rotavirus-cholera combined vaccine and a preparation method thereof. The vaccine comprises: a. cholera vaccine, comprising Vibrio cholerae enterotoxin protein (CT) and a combined protein adjuvant, wherein the combined protein adjuvant is passed The gene recombination is constructed at one end of the Vibrio cholerae enterotoxin B subunit protein, and the Vibrio cholerae enterotoxin A subunit protein and the Vibrio cholerae enterotoxin B subunit protein are connected through a connecting segment to form a recombinant CT whole protein as an antigen; and b. Rotavirus vaccine. The rotavirus-cholera combined vaccine of the present invention uses recombinant protein subunits as carriers to connect homologous toxic protein subunits. The recombinant protein not only has a good carrier function, but also enables better and faster entry of toxic subunits. In the cells of the vaccinated person, an immune response is triggered. At the same time, the recombined protein carrier also has a good adjuvant effect, which can stimulate the body to produce a mucosal immune response and improve the resistance of the vaccinated person to the antigen. |
| priorityDate |
2017-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |