| abstract |
The present invention provides the compound of formula (I), wherein, R 1 is OR 11 or NR 5 R 5' ; R 2 is H or F; R 5 is H, C 1 -C 6 alkyl, OH, C(= O)R 6 , O(C=O)R 6 or O(C=O)OR 6 ; R 5 ' is H or C 1 -C 6 alkyl; R 6 is C 1 -C 6 alkyl or C 3 -C 7 cycloalkyl; R 13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl, wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl are optionally 1, 2 or 3 R 22 substitutions; other variables are as defined in the claims, and the compounds are useful in the treatment of cancer and related aspects. |