| abstract |
The present disclosure generally relates to capsaipine derivatives and methods of their use. In some aspects, the present disclosure relates to the use of capsaipine derivatives to treat cancer or other hyperproliferative diseases. In some aspects of the present disclosure, the present disclosure provides capsaipine derivatives useful in the treatment of cancer. Such cancers for which the compounds are useful for treatment include, but are not limited to, breast cancer, cervical cancer, oral cancer, head cancer, neck cancer or prostate cancer. In some aspects, the compounds may be used to treat tumors by injecting the compounds directly into tumors, particularly oral tumors. In other aspects, the compounds are administered systemically. Compounds of the disclosure are also useful in the treatment of pain associated with tumors to which the compounds are administered. |