| abstract |
The present invention relates to field of biotechnology, and in particular to a kind of CAR.IL-33-T cell and its preparation and application.Present invention firstly provides a kind of Chimeric antigen receptor T cell, expression targets the Chimeric antigen receptor (CAR) and interleukin-33 (IL-33) of tumour antigen.Compared with CAR-T cell, CAR.IL-33-T cell, which has, stronger kills tumor function.And confirm that CAR.IL-33-T cell is a kind of safe, special, effective CAR-T cell, there is important clinical value. |