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filingDate 2017-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2019-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2019-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-107056983-B
titleOfInvention Prepare orthogonal regulation mechanical performance and medicine-releasing performance double-network hydrogel method
abstract The invention discloses the double-network hydrogel methods that a kind of preparation of photo-crosslinking has orthogonal regulation mechanical performance and medicine-releasing performance, include: (1) using polyacrylic acid and mono amino beta cyclodextrin as reactant, the polyacrylic acid powder of grafting beta cyclodextrin is prepared;(2) polyacrylic acid powder for being grafted beta cyclodextrin is dissolved in phosphate buffer, and acrylamide, N ' N- methylene-bisacrylamide and photoinitiator is added, after being uniformly mixed, be crosslinked under ultraviolet light.This method simple process, short preparation period, size is controllable, and repeatability is strong, and stability is good.The regulation orthogonal with the release performance to drugs such as polypeptides of the mechanical performance of prepared double-network hydrogel, does not interfere with each other.Wherein a weight network controls mechanical strength by adjusting polymer network, and a weight network regulates and controls sustained release by adjusting with the affinity of drug molecule.The double-network hydrogel biological medicine, in terms of be with a wide range of applications.
priorityDate 2017-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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