| abstract |
The present invention relates to novel monoclonal antibodies that specifically bind to delta-like ligand 4 (DLL4), and in particular to a monoclonal antibody that specifically binds to human delta-like ligand 4 to effectively inhibit the interaction between delta-like ligand 4 and Notch receptors Cloned antibody, polynucleotide encoding the monoclonal antibody, expression vector including the polynucleotide, transformant including the expression vector, method for preparing the monoclonal antibody, use for the prevention or treatment of cancer including the monoclonal antibody The pharmaceutical composition, the composition for diagnosing cancer comprising the monoclonal antibody, the method for diagnosing cancer using the monoclonal antibody, and the pharmaceutical composition comprising the monoclonal antibody for preventing or treating autoimmune diseases. |