http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107056784-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-22 |
| filingDate | 2017-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107056784-B |
| titleOfInvention | Chiral dihydroxyindole spiro-compound and synthesis method thereof |
| abstract | The invention discloses a method for synthesizing a chiral dihydroxyindole spiro-compound, in particular to a chiral dihydroxyindole spiro-compound derived from 3-pyrrolyl oxindole and isatinn β ,n γ -unsaturationn α Ketoesters as reactants in chiral (Box)/Cu (II) complexes with quinidine, p-toluenesulfonic acid or DB, respectivelyIn the presence of U, the product is synthesized by asymmetric Friedel ‒ Crafts/Aldol serial cyclization reaction in a metaxylene solvent. The method disclosed by the invention has the advantages of simple and easily-obtained raw materials, mild reaction conditions, simple and convenient post-treatment, wide applicable substrate range, high yield, high enantioselectivity and diastereoselectivity; the product synthesized by the method has potential medicinal value. |
| priorityDate | 2017-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 63.