| abstract |
The invention discloses thiocarbamide and oxazolidine thione class compound and its synthetic method and applications shown in a kind of formula (3) and formula (5), in reaction dissolvent, with primary amine, the aminated compounds such as secondary amine are raw material, using inorganic sulphide reagent as sulphur source, single carbon halogenated hydrocarbons is single carbon source, and in the presence of alkali, reaction obtains the formula (3), formula (5) thiocarbamide and oxazolidine thione class compound.Synthetic method raw material of the present invention is cheap and easy to get, operation is simple, functional group tolerance is strong, avoid volatile and inflammable carbon disulfide, the thiophosgene of high toxicity and strong corrosive, the use of the main thiocarbonyl group reagent such as lawesson reagent or phosphorus pentasulfide of high toxicity and foul smell, and it is applied successfully to chiral thiourea catalyst, the synthesis of chiral oxazolidine thione prothetic group and commercialization pesticide gram-grade scale.The present invention has stronger practical value and broad application prospect. |