http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107050452-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1845 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-186 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-126 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 |
| filingDate | 2017-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107050452-B |
| titleOfInvention | Magnetic nano-particle modified by aptamer and preparation method and application thereof |
| abstract | A magnetic nanoparticle modified by aptamer and a preparation method and application thereof are disclosed, wherein the surface of the magnetic nanoparticle is coated with a layer of PEG phospholipid molecules, and the PEG is connected with the aptamer. The nanoparticle of the invention comprises a magnetic core positioned in a core, PEGylated phospholipid coated on the surface of the magnetic core and aptamer connected with PEG. The magnetic core has good superparamagnetism and excellent magnetocaloric effect, the internal stability and biocompatibility of the magnetic core are improved by coating the PEGylated phospholipid on the outer layer, and the function of targeting tumor tissues is realized by connecting a nucleic acid aptamer. The particles can be injected intravenously to realize MRI imaging diagnosis and thermotherapy of tumors in vivo. |
| priorityDate | 2017-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.