abstract |
The present invention provides a sterile water-based or sterile oil-based debridement composition comprising (i) at least 70% guluronic acid or guluronic acid radical residues and 2- Alginic acid oligomers with a degree of polymerization of 100, (ii) at least one proteolytic enzyme and/or at least one abrasive solid phase. The present invention also provides a product comprising an alginic acid oligomer and a second active agent as a combined formulation to be used separately, simultaneously or sequentially to combat biofilms or to treat or prevent biofilm infections in a subject , wherein the alginic acid oligomer has at least 70% guluronic acid or guluronic acid radical residues and a degree of polymerization of 2 to 100; wherein the second active agent is selected from: (i) Antimicrobial agents, (ii) other biofilm disrupting and/or mucosal viscosity reducing agents, (iii) immunostimulants, (iv) growth factors, or (v) anti-inflammatory agents. |