http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107041888-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4baf61b82705468dd1ff913b8ce785f7 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-77 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-555 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-555 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-77 |
| filingDate | 2017-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52317fed040bae1707d618b06c92cc33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50a21ac0e35be37fcd61430c84227ef9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_665de77f90b8f5a5690dd55e70e9719d |
| publicationDate | 2017-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107041888-A |
| titleOfInvention | A kind of chloro-salicylic aldehyde of cancer therapy drug 5 contracting hydrazino pyridine schiff bases cobalt complex of 2 bromine 6 and synthetic method |
| abstract | A kind of chloro-salicylic aldehyde of cancer therapy drug 5 contracting 2 bromine 6 hydrazino pyridine schiff bases cobalt complex [Co (bhcp) 2 ] 2 And synthetic method.The cobalt complex [Co (bhcp) 2 ] 2 Molecular formula be：2(C 24 H 16 Br 2 Cl 2 CoN 6 O 2 ), molecular weight is：1420.15g/mol, Hbhcp are the 5 chloro-salicylic aldehydes contracting hydrazino pyridine schiff bases of 2 bromine 6.By analytically pure 5 chloro-salicylic aldehydes of 1.565g, the analytically pure hydrazino pyridines of 2 bromine 6 of 1.880g are dissolved in 30mL analysis straight alcohol solution, part Hbhcp are obtained after being heated to reflux two hours.Dried 0.157 0.314g Hbhcp are dissolved in 5 10mL and analyze pure DMF, 0.145 0.291g analyzes pure cabaltous nitrate hexahydrate and is dissolved in 5 10mL analysis straight alcohols, it is placed in reactor, three days is stood in 80 DEG C of baking ovens, has red bar crystal to generate i.e. [Co (bhcp) 2 ] 2 。[Co(bhcp) 2 ] 2 There is certain inhibition to JEG-3, but cis-platinum is far below to toxicity to the normal liver cells of HL 7702 strain cell, be a kind of inorganic cancer therapy drug.Present invention process is simple, with low cost, chemical constituent is easily controllable, reproducible and yield is high. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113583028-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113583028-B |
| priorityDate | 2017-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.