http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107038349-B

Outgoing Links

Predicate Object
classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B20-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6869
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B20-00
filingDate 2016-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2020-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2020-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-107038349-B
titleOfInvention Method and apparatus for determining pre-rearrangement V/J gene sequence
abstract The invention discloses a method for determining a V and/or J gene sequence before rearrangement, which comprises the following steps: (1) obtaining sequencing data of the RNA sample to be tested, wherein the sequencing data comprises a plurality of reads from variable regions of TCR, BCR and/or Ig; (2) determining a portion from the V/J gene segment on the read based on the sequencing data according to the arrangement relationship of V, J and the C gene segment in the variable region, obtaining a plurality of V/J region portions; (3) taking at least one sequence from each V/J region part as a seed sequence to obtain a seed sequence set comprising a plurality of seed sequences; (4) clustering the V/J area parts according to the difference of the support number of the V/J area parts of each seed sequence to obtain a plurality of V/J area part clusters; (5) extending the seed sequence supported by each V/J region part cluster by using each V/J region part cluster to obtain a plurality of candidate V/J gene sequences before rearrangement; (6) and filtering the support condition of the candidate V/J gene sequence before rearrangement by using the reading segment to obtain the V/J gene sequence before rearrangement.
priorityDate 2016-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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