http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107033162-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-24 |
| filingDate | 2016-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107033162-B |
| titleOfInvention | Preparation of 7-phenylacetamide-3-chloromethyl cephalosporanic acid p-methoxybenzyl ester |
| abstract | The invention belongs to the field of cephalosporin drug intermediate synthesis, and discloses a preparation method of 7-phenylacetamide-3-chloromethyl cephalosporanic acid p-methoxybenzyl ester (GCLE for short), which takes penicillin G sylvite as an initial raw material, firstly reacts with p-methoxybenzyl chloride, peroxyacetic acid is oxidized to prepare penicillin sulfoxide ester, the penicillin sulfoxide ester firstly reacts with 2-mercaptobenzothiazole, then reacts with benzene sulfinic acid to obtain an open ring substance, the open ring substance reacts with chlorine, and under the action of methanol solvent, sodium methoxide is used for ring closure to obtain the 7-phenylacetamide-3-chloromethyl cephalosporanic acid p-methoxybenzyl ester. |
| priorityDate | 2016-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.