http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107033043-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C319-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-40 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C319-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-25 |
| filingDate | 2016-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107033043-B |
| titleOfInvention | N- replaces benzenesulfonyl-substituted benzene formyl amine compound and its prepares the purposes of drug |
| abstract | The present invention relates to a kind of N- replace benzenesulfonyl-substituted benzene formyl amine compound, crystal form, pharmaceutically acceptable salt class, hydrate, solvate or prodrug, and preparation method thereof and pharmaceutical applications.Shown in the general structure of the compound such as formula (I).Experiment shows itself and Bcl-2, Bcl-x L There is preferable binding ability with Mcl-1 albumen, preferable broad-spectrum anti-tumor activity is shown to human blood tumour (leukaemia, myeloma) and solid tumor (oophoroma, breast cancer, melanoma, lung cancer).Therefore there is these compounds preparation the therapeutic agent of relevant disease is expressed to Bcl-2 protein family anti-apoptotic members height, prepare anti-tumor drug, and prepares synergist and share with other anti-tumor drugs or radiotherapy to treat the potential use of tumour. |
| priorityDate | 2016-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 154.