| abstract |
The present invention provides is used to prepare 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonyl ethyl]-4-acetylaminoisoindoline-1 ,A new process for aminosulfone intermediates in the synthesis of 3-diketones, 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetyl Aminoisoindoline-1,3-dione is useful in the prevention or treatment of diseases or conditions associated with abnormally high levels or activity of TNF-alpha. Further provided by the present invention is a process for the commercial production of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine. |