http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107033010-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_67068c0d95f977412b821eb313b7f70f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F3-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-70 |
| filingDate | 2017-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd631260fb96ea5293bab347508f70d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab2a9a53935f7b76c9af63e636a9edab |
| publicationDate | 2017-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107033010-A |
| titleOfInvention | A kind of method of asymmetric syntheses anti-AIDS drug efavirenz key intermediate |
| abstract | The invention discloses a kind of method of asymmetric syntheses anti-AIDS drug efavirenz key intermediate, belong to medical synthesis technical field.Including 2 methyltetrahydrofurans, alkaline reagent, alcohol compound, chiral aminoalcohol solution, cyclopropyl acethlene are reacted, after add the amino trifluoro-benzene ketone of 5 chlorine 2 occur addition reaction, again by terminating reaction liquid terminating reaction, the chlorine a cyclopropyl acethlene a trifluoromethyl benzyl alcohols of key intermediate (S) 2 amino 5 of efavirenz are obtained.Avoiding needs the operating process of the lithium salts, sodium salt or its RMgBr that first prepare cyclopropyl acethlene in industrial production, significantly reduce the operation difficulty and cost of reaction, is adapted to industrialized production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113880693-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113880693-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114920268-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114920268-B |
| priorityDate | 2017-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 77.