http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107028888-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-183 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2017-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107028888-B |
| titleOfInvention | Drug-resistant liposome actively targeting tumor EMT cells and preparation method thereof |
| abstract | The invention provides a novel drug-resistant liposome actively targeting tumor EMT cells and a preparation method thereof, belonging to the field of pharmaceutical preparations. Preparing cyclopentapeptide-polyethylene glycol-phospholipid by taking distearoyl phosphatidyl acetamide-N-hydroxysuccinimide-polyethylene glycol and cyclopentapeptide ADH-1 as raw materials; dissolving lecithin, cholesterol, methoxy-polyethylene glycol-phospholipid and cyclic pentapeptide-polyethylene glycol-phospholipid in chloroform according to a certain molar ratio, and performing rotary evaporation under reduced pressure to form a uniform and transparent lipid membrane; adding preheated phosphate buffer solution, whirling, vibrating, hydrating until the lipid membrane completely falls off, crushing the lipid membrane, and purifying with Sephadex column to obtain novel drug-resistant liposome. The preparation method is simple, the technology is mature, the application prospect is wide, the obtained novel drug-resistant liposome is modified by the cyclic pentapeptide-polyethylene glycol-phospholipid, and the active targeting property is realized on tumor EMT cells. |
| priorityDate | 2017-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 99.