http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107028882-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 |
| filingDate | 2017-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107028882-B |
| titleOfInvention | Physically-wrapped tumor-targeted nano drug delivery system, and preparation method and application thereof |
| abstract | The invention discloses a physically-wrapped tumor targeted nano drug delivery system, a preparation method and application thereof, wherein a low-waist system of the system comprises a targeted element modified by RGERPPR polypeptide, a nano micelle and an anti-tumor drug, and the targeted element is distearoyl phosphatidyl ethanolamine-polyethylene glycol-RGERPPR; the micelle is a polyglutamic acid PGG macromolecular skeleton and a glutamic acid branched chain on the skeleton; the anti-tumor drug is paclitaxel PTX. The tail end of a glutamic acid branched chain of a polyglutamic acid macromolecular skeleton is bonded with an antitumor drug PTX through an ester bond to form PGG-PTX, and then the PTX and distearoyl phosphatidyl ethanolamine in a targeting element wrap the distearoyl phosphatidyl ethanolamine at the hydrophobic end of the targeting element into the PGG-PTX through hydrophobic interaction to form a targeted antitumor nano drug delivery system. The drug delivery system can be used for targeted delivery of tumor treatment drugs, obtains good curative effect on treatment of the brain glioma, and prolongs the median survival time of BALB/C brain glioma nude mice. |
| priorityDate | 2017-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.