| abstract |
The invention discloses a kind of preparation methods of multiple response self-healing hydrogel.The hydrogel is to form dynamic imine linkage by schiff base reaction in aqueous solution, crosslinking is prepared using the cladodification polyethyleneimine of aldehyde radical pulullan polysaccharide, rich amino-containing epsilon-polylysine and low molecular weight as raw material.Operation of the present invention is simple, raw material is environmentally protective and cheap, and preparation is not necessarily to organic solvent, and cycle period is short, hydrogel obtained has temperature and pH-sensitivity, syringeability and good self-healing performance, these performances make hydrogel have extensive bio-medical prospect. |