http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107011430-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-70 |
| filingDate | 2017-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107011430-B |
| titleOfInvention | Truncated growth differentiation factor 11 with biological activity and preparation method thereof |
| abstract | The invention discloses a truncated growth differentiation factor 11(GDF11) with biological activity and a preparation method thereof, belonging to the technical field of biological medicines. The truncated growth differentiation factor 11 consists of 95 amino acids, and the amino acid sequence of the truncated growth differentiation factor is shown as SEQ ID NO. 1. The biological activity of the truncated growth differentiation factor 11 obtained by the invention is researched, and the result shows that the truncated GDF11 can stimulate the collagen secretion of fibroblasts, and has the activity of promoting the phosphorylation of myocardial fibroblasts Smad2/3 and activating the Smad2/3 pathway of the myocardial fibroblasts. Therefore, further, the truncated growth differentiation factor 11 of the present invention will have a wide application in the treatment or prevention of irreversible senile diseases such as diastolic heart failure, Alzheimer's disease, etc. |
| priorityDate | 2017-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 126.