| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C259-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C259-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-166
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C259-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C259-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate |
2017-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2020-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2020-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-107011238-B |
| titleOfInvention |
Histone deacetylase inhibitor and preparation method and application thereof |
| abstract |
A histone deacetylase inhibitor and a preparation method and application thereof relate to the field of pharmaceutical chemistry. The compound has stronger HDAC inhibition activity and capability of inhibiting cancer cell proliferation than reference medicaments of the cidam and the CI 994. Especially has excellent activity of inhibiting the proliferation of human liver cancer cells HepG2 and human lung cancer cells A549. The compounds have the structure shown in the following general formula I, wherein R and Z are defined in the specification of the application. |
| priorityDate |
2017-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |