Predicate |
Object |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2517-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0393 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-02 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-907 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0278 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0606 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
filingDate |
2015-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2021-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate |
2021-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CN-107002093-B |
titleOfInvention |
Methods and compositions for targeted genetic modification, and methods of using these compositions |
abstract |
The present invention provides methods and compositions for generating targeted genetic modifications on the Y chromosome or challenging target loci. Compositions include in vitro cultures comprising modified XY pluripotent and/or totipotent animal cells (i.e., XY ES cells or XY iPS cells) having reduced Sry protein levels and/or activity; These cells were grown in medium for the development of F0 fertile females. Such compositions can be applied to various methods of producing fertile female XY non-human mammals in the FO generation. |
priorityDate |
2014-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |