| abstract |
The present invention discloses compounds having cytotoxic and/or antimitotic activity. The invention also discloses methods related to the preparation and use of such compounds, and pharmaceutical compositions containing such compounds. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a cytotoxic and/or or compounds with antimitotic activity. |