| abstract |
Certain 1-[2-(aminomethyl)benzyl]-2-thio-1,2,3,5-tetrahydro-4H-pyrrolo[3,2- d] pyrimidin-4-one compounds, and pharmaceutically acceptable salts thereof, as well as compositions containing these compounds and the use of these compounds and compositions in therapy. These compounds are inhibitors of the enzyme MPO and are therefore particularly useful in the treatment or prevention of cardiovascular disorders, such as heart failure and coronary artery disease related conditions. |