| abstract |
The present invention relates to substituted indole or indazole pyrimidine derivatives and their preparation method, pharmaceutical composition and application. Specifically, it relates to a compound of formula I or a pharmaceutically acceptable salt or solvate thereof, wherein R 1 -R 7 , and the definitions of X and Y are as described in the specification and claims. The present invention also relates to the preparation method of the compound of formula I, including its pharmaceutical composition and their pharmaceutical use. The compound of formula I of the present invention is an effective irreversible inhibitor of tyrosine kinase, especially has strong inhibitory effect on EGFR-T790M drug-resistant tumors. |