| abstract |
The invention discloses an FXR agonist, a preparation method and application thereof, and specifically relates to a compound having a structure of formula (I), its stereoisomer or a pharmaceutically acceptable salt thereof. This series of compounds can be used to treat diseases mediated by FXR, including cardiovascular disease, atherosclerosis, arteriosclerosis, hypercholesterolemia, hyperlipidemia, chronic hepatitis disease, chronic liver disease, gastrointestinal disease, kidney disease, cardiovascular disease, Diseases such as metabolic diseases, cancer (such as colorectal cancer) or neurological indications such as stroke have a wide range of medical applications and are expected to be developed into a new generation of FXR modulators. |