http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106986901-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H13-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H13-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 |
| filingDate | 2017-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106986901-B |
| titleOfInvention | Sialic acid-carboxylic acid compound conjugate and preparation method thereof |
| abstract | The sialic acid-carboxylic acid compound conjugate is obtained by direct glycosidation reaction of a sialic acid thioglycoside donor and a carboxylic acid compound, and is a compound with sialic acid and carboxylic acid ester at the anomeric position, the preparation method comprises ⑴ steps of sequentially adding the sialic acid thioglycoside donor, a newly activated molecular sieve and the carboxylic acid compound into a reaction vessel, adding redistilled dichloromethane for dissolving, argon protecting, stirring for 15 minutes at 25 ℃, ⑵ steps of rapidly adding boron trifluoride diethyl etherate and iodosuccinimide into the activation system, stirring and reacting for 5-10 minutes at 25 ℃, ⑶ steps of filtering the reaction system, diluting the reaction system with an organic solvent, washing the organic phase once with a saturated sodium thiosulfate solution, extracting the aqueous phase with the organic solvent for three times, combining the organic phase, drying with anhydrous sodium sulfate, filtering, spin-drying, and eluting by silica gel column chromatography to obtain the sialic acid-carboxylic acid compound conjugate. |
| priorityDate | 2017-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.