http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106986854-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_34ef52c68d9267a3ebf4c0d592a7cb6e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2016-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33d1086ee462806c558cbe5d2349a06d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38841ce3e2d3e19b3b04afbc8d06c2fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_464aa9ad8094d9a6705751d0452fa8ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a2b1d3a28e885c9e6760fea5ce18000 |
| publicationDate | 2017-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106986854-A |
| titleOfInvention | A kind of myrrh alkyl sesquiterpene structural analogue and its preparation method and application |
| abstract | The invention discloses a myrrh alkane sesquiterpene structural analogue, a preparation method and application thereof. The structural formula of the bisabolyl sesquiterpene structural analogue provided by the present invention is shown in Formula I. The preparation method of the compound shown in the formula I provided by the present invention comprises the following steps: 1) 4-bromo-2-thiophene carboxaldehyde and p-cyanophenylboronic acid obtain the compound shown in the formula II through Suzuki coupling reaction; (2) the compound shown in the formula II The compound shown in the formula III is obtained through the Knoevenagel condensation reaction with methylmalonic acid; (3) the product of the compound shown in the formula III reacted with thionyl chloride is reacted with ammonia water in an ice bath to obtain the compound shown in the formula I The compounds shown in the formula I provided by the present invention or pharmaceutically acceptable salts thereof can be used to prepare anti-tumor drugs. Anti-tumor drugs can inhibit the proliferation of tumor cells. The tumor cells can be breast cancer cells, cervical cancer cells and/or ovarian cancer cells. Breast cancer cells can be specifically MCF‑7 cells, cervical cancer cells can be specifically HeLa cells, ovarian cancer cells Specifically, cancer cells can be HO8910 cells. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110016011-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112245424-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112245424-B |
| priorityDate | 2016-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.