| abstract |
The invention provides a method for efficiently synthesizing thioether ketone derivatives containing different heterocyclic rings, which uses KI as a catalyst, potassium persulfate as an oxidant, and reacts carbonyl compounds with benzoheterocyclic thiols at room temperature Substrate, the reaction system added DMSO as a solvent. The advantages of this method are that the catalyst is cheap and easy to obtain; the reaction condition is mild, and it can take place at room temperature, which is safe and reliable; the yield of the obtained target product is as high as 94%. This method solves the disadvantages of the traditional heterocyclic thioetherification reaction that the substrate is expensive, requires multi-step reactions, and harsh reaction conditions, and has good industrial application prospects. |