http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106986766-B

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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-10
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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-736
filingDate 2017-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2021-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-106986766-B
titleOfInvention Preparation method of tafluprost
abstract The invention discloses a preparation method of tafluprost, which comprises the steps of taking a compound shown in a formula 1 as a raw material, and carrying out DIBAL-H reduction, Wittig reaction and esterification reaction; wherein, basic amino acid is adopted for refining after the wittig reaction. The total mass yield of the three-step reaction of the preparation method can reach 70 percent, the process is stable, the prepared tafluprost product is colorless to light yellow viscous oily liquid, and the purity is as high as more than 99 percent.
priorityDate 2017-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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