http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106967623-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12R2001-685 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-02 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-685 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-14 |
| filingDate | 2017-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106967623-B |
| titleOfInvention | Aspergillus niger for producing taxane compound baccatin III and application thereof |
| abstract | The invention discloses an endophyte which is separated and screened from tissues of torreya grandis of Taxaceae and produces taxane compound baccatin III, and the endophyte is named as Aspergillus niger BP12 +/-3 through classification identification, and the preservation number is CCTCC NO: M2016319. The strain has the activity of resisting staphylococcus aureus and escherichia coli, the content of a crude extract of a taxol analogue in fermentation liquor can reach 120mg/L, wherein the relative percentage content of a taxane compound baccatin III is 10.5%, the yield is 12.6mg/L, and is higher than the yield disclosed in the prior art; the yield of baccatin III can be increased by 129.84% by using L-phenylalanine as precursor. The CCK-8 reagent method is adopted to prove that the fermentation liquor extract of the Aspergillus niger BP12 +/-3 has the inhibition effect on Hela tumor cells, and the inhibition rate can reach 62.91%. |
| priorityDate | 2017-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.