http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106967072-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-02 |
| filingDate | 2017-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106967072-B |
| titleOfInvention | Tofacitinib citrate crystal form compound and preparation method thereof |
| abstract | The invention belongs to the technical field of medicines, and discloses a tofacitinib citrate crystal form compound and a preparation method thereof, wherein an X-ray powder diffraction pattern represented by a 2 theta +/-0.2-degree diffraction angle shows characteristic diffraction peaks at 2.42 degrees, 3.25 degrees, 4.23 degrees, 5.04 degrees, 6.12 degrees, 7.08 degrees, 8.02 degrees, 9.72 degrees, 10.63 degrees, 12.90 degrees, 14.35 degrees, 15.71 degrees, 17.82 degrees, 18.34 degrees, 19.24 degrees, 22.46 degrees, 24.56 degrees, 26.62 degrees, 30.75 degrees and 32.45 degrees, and an X-ray powder diffraction pattern obtained by using Cu-K alpha ray measurement is shown in figure 1 and is completely different from the prior art. The tofacitinib citrate crystal form compound has good water solubility and high stability, the preparation method is simple and easy to operate, the administration safety of the prepared pharmaceutical composition is greatly improved, and the tofacitinib citrate crystal form compound is very suitable for clinical application. |
| priorityDate | 2017-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.