http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106966941-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-54 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-08 |
| filingDate | 2017-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106966941-B |
| titleOfInvention | The method that overcritical compression Anti-solvent Precipitation prepares ezetimibe ultrafine dust |
| abstract | The present invention relates to the methods that the overcritical compression Anti-solvent Precipitation of application prepares ezetimibe ultrafine dust, comprising: ezetimibe bulk pharmaceutical chemicals are dissolved in organic solvent, prepare ezetimibe solution；By CO 2 It is passed through crystallization kettle with certain volume flow, adjusts the temperature and pressure in crystallization kettle, and maintain stable state；The ezetimibe solution prepared before is passed through crystallization kettle with preset sample introduction flow velocity；After sample introduction, it is continually fed into CO 2 , whole process maintain crystallization kettle in temperature and pressure it is constant, release after a period of time；Pressure in kettle to be crystallized be down to it is equal with atmospheric pressure after, open crystallization kettle collect ezetimibe ultrafine dust, carry out a series of phenetic analysis later.Compared with untreated bulk pharmaceutical chemicals, ezetimibe ultra-fine grain particle size produced by the present invention is reduced by about 80% and crystal form does not change.On technological layer, the present invention has operating condition mild, green high-efficient, almost the advantages that no solvent residue. |
| priorityDate | 2017-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 19.