| abstract |
The invention discloses a condensed polycyclic indoline compound, its preparation method, pharmaceutical composition and application. The compound provided by the present invention has obvious inhibitory effect on tumor cells Kyse-450, MDA-MB-231 and SKGT-4, and has significant biological activity to chloroquine-resistant Plasmodium falciparum dd2; at the same time, the preparation method of the present invention The reaction yield is high, the synthesis steps are short, the range of applicable substituents is wide, the operation is simple, and the industrial application prospect is expected to be realized. |