| abstract |
The invention discloses a VHH structural domain and a single domain antibody of an anti-CEA antigen, and a bispecific antibody containing two VHH structural domains, wherein the antibody is formed by fusing two different heavy chain sequences and can respectively identify different epitopes of the CEA antigen. The VHH structural domain, the single domain antibody and the bispecific antibody have excellent antibody recognition capability, obvious ADCC effect and longer in-vivo half-life, and have wide application prospects in the fields of in-vitro and in-vivo diagnosis and medicament preparation. |