| abstract |
The present invention relates to a preparation method of diastereoisomer compound I, said method comprising the following steps: compound III is heated and stirred in an organic solvent to transform its configuration to obtain compound I, wherein X group The group is a halogen; compared with the prior art, the preparation method of the present invention has cheap and easy-to-get raw materials, mild reaction conditions, few side reactions, high yield, little environmental pollution, and is suitable for industrialized production. It is tenofofumarate The preparation of the key intermediate of Vilafenamide provides a new way. |