http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106946725-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C215-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-28 |
| filingDate | 2017-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106946725-B |
| titleOfInvention | Alkamine neuraminidase inhibitor and preparation method thereof |
| abstract | The invention discloses alkamine neuraminidase inhibitors and preparation method thereof.Method of the invention is specific as follows: (1) by cinnamic acid, lithium perchlorate LiClO 4 ·3H 2 O and trimethylsilyl cyanide TMSCN react to obtain cyano analog；(2) under reducing agent and Additive, cyano analog is restored to obtain the amino compound that hydroxyl replaces；(3) amino compound and acyl chlorides that hydroxyl replaces are reacted under alkaline condition, obtains a kind of neuraminidase inhibitor；(4) amino compound that hydroxyl replaces and substituted benzyl bromide are reacted under alkaline condition, obtains the neuraminidase inhibitor of another structure.The compound structure that the present invention synthesizes is novel, has shown preferable inhibition neuraminic acid enzyme inhibition activity. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108383805-B |
| priorityDate | 2017-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 217.